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Folate is a water-soluble B vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. “Folate,” formerly known as “folacin” and sometimes “vitamin B9,” is the generic term for naturally occurring food folates, and folates in dietary supplements and fortified foods, including folic acid. Food folates are in the tetrahydrofolate (THF) form and usually have additional glutamate residues, making them polyglutamates [1]. Folic acid is the fully oxidized monoglutamate form of the vitamin that is used in fortified foods and most dietary supplements. Some dietary supplements also contain folate in the monoglutamyl form, 5-methyl-THF (also known as L-5- MTHF, 5-MTHF, L-methylfolate, and methylfolate).